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In vitro scientific studies, 25C-NBOMe is shown to exhibit cytotoxicity on neuronal mobile lines SH-SY5Y, PC12, and SN471, and the compound was far more potent than methamphetamine at lessening the visibility on the respective cells; the neurotoxicity with the compound entails activation of MAPK/ERK cascade and inhibition of Akt/PKB signaling pathw